Teoresi logo

IO.T Solutions new section

projects

OTERO

Advancing Cancer Treatment through Precision Synchronization

OTERO

Advancing Cancer Treatment through Precision Synchronization

A Teoresi Group project
Project

The Otero project implements the system that synchronizes all the high-tech components of the synchrotron at the CNAO Foundation’s facility in Pavia. The National Center for Oncological Hadrontherapy (CNAO) is the only facility in Italy capable of providing hadron therapy treatments using protons and carbon ions. Worldwide, there are only six centers capable of applying this therapy, including CNAO in Pavia. The success of the timing and utilization of the proton and carbon ion particle beam has allowed for the optimization of the accelerator’s occupancy time, safeguarding the time dedicated to patient treatment while also improving access to this technique for research and experimentation.  

Client

logo-1
infn-logo-sito-1
Industries
Scenario

Hadron therapy is an advanced form of radiotherapy that, instead of using X-rays, employs protons and carbon ions, allowing the energy of the particles to be delivered in an extremely localized and controllable manner without causing damage to surrounding tissues or organs. These particles are heavier and have more energy than electrons, making them even more effective in treating certain cancers, including radioresistant tumors or those considered inoperable. This creates the need to extend the facility’s performance to explore new treatment cycles and increase the number of patients treated. 

Challenges

The main technological challenges of the project were: 

  • Upgrading the existing hardware while maintaining backward compatibility with pre-existing and operational devices. 
  • Fast and careful distribution of synchronization updates to minimize treatment interruptions. 
  • Defining a mixed architecture with particular attention to the trade-off between off-the-shelf (COTS) components and custom-developed components, as well as the tools necessary for development. 
Our added Values

Our intervention was crucial in terms of expertise and added value in the following activities: 

  • Supporting the definition of the architecture and the correct trade-off between off-the-shelf boards and custom-designed boards. 
  • Designing custom boards, which required technological expertise in HW design and the generation of files necessary for production. 
  • Defining the FPGA architecture, clock tree, synchronization distribution and locking mechanisms, and the protocol transmitted over fiber. Developing the FPGA code, Place and Route, verification, and validation. 
  • Conducting extensive and structured Verification and Validation activities for a medical project like this, which required expertise across various technological domains (electronics, FPGA, firmware, system). 
 
Results

Overall, in the project, we contributed to both qualitative and quantitative improvements. Specifically, we were responsible for: 

  • Implementing the system, using a National Instruments COTS platform, which ensured a high degree of modularity and integration with custom-developed hardware boards. This resulted in a subsystem with a good balance between performance, scalability, and cost. 
  • Optimizing and automating operations in particle beam management, which enabled the treatment of more patients within the same timeframe (a 5% increase in treatments with the ion species generated at the time of commissioning). Meanwhile, the time allocated for experimentation increased by up to 25%, bringing the overall usage of the accelerator to nearly 90%. 
  9
Projects You may also be interested in